1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7-tris(1-methyl-1-phenylethyl) ester - Names and Identifiers
Name | 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7-tris(1-methyl-1-phenylethyl) ester
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Synonyms | DOTA-tri(α-cumyl Ester) 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7-tris(1-methyl-1-phenylethyl) ester
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CAS | 1412494-57-5
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1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7-tris(1-methyl-1-phenylethyl) ester - Physico-chemical Properties
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7-tris(1-methyl-1-phenylethyl) ester - Introduction
1,4,7, 4,7,10-tetraacetic acid, 1,4,7-tris(1-methyl-1-phenylethyl) ester is an organic compound commonly abbreviated as DOTA-Me3. It is a compound with a macrocyclic receptor structure with properties similar to EDTA (ethylenediaminetetraacetic acid).
The nature of this compound: DOTA-Me3 is a solid, usually white or brown crystals. It has high thermal stability and solubility, and can be dissolved in some non-polar solvents. It exhibits good stability and low acid dissociation constant in aqueous solution, which makes it widely used in coordination chemistry and pharmaceutical formulations.
Uses: The most common use of DOTA-Me3 is as a contrast agent for MRI (magnetic resonance imaging) and a carrier for radioisotope therapy in biomedicine. Its macrocyclic structure helps to stabilize the metal ion, making it less distributed and potentially toxic in the body. In addition, DOTA-Me3 has also been used in the synthesis of antitumor and antiviral drugs related to metal ions.
Preparation method: A common preparation method of DOTA-Me3 is to combine 1,4,7,10-tetraaminocyclododecane with 1,4, esterification of 7-tris (1-methyl -1-phenylethyl) alcohol to form an ester bond under appropriate reaction conditions.
Safety Information: DOTA-Me3 are generally considered relatively safe compounds, but care should be taken to avoid direct skin contact and inhalation of dust. Follow appropriate laboratory practices and pay attention to personal protective measures during use.
Last Update:2024-04-09 02:00:51